Research Interests

My research interests lie broadly in the application of simulation, optimization, and data analysis to support health care decision-making. I am currently interested in efficient learning in clinical trials, precision medicine, screening and treatment of cancer (thyroid and lung), and health care in the intensive care unit (ICU).

Published Work

• Value-Based Clinical Trials: Selecting Trial Lengths and Recruitment Rates in Different Regulatory Contexts with S.E. Chick and M. Forster. Management Science 2022.
  • Finalist of the POMS College of Healthcare Operations Management Best Paper Competition 2021
• Resource Allocation with Sigmoidal Demands: A Data-Driven Approach to Managing Mobile Healthcare Units with Philippe Blaettchen, Harwin de Vries, and Luk N. Van Wassenhove. M&SOM 2021.
• Cost-Effective Clinical Trial Design: Application of a Bayesian Sequential Stopping Rule to the ProFHER Pragmatic Trial with M. Forster, S. Brealey, S.E. Chick, A. Keding, B. Corbacho, and A. Rangan. Clinical Trials 2021.
• ICU Capacity Management During the COVID-19 Pandemic Using a Stochastic Process Simulation with S.E. Chick, D.A. Dongelmans, A.F. van der Sluijs, W.J. Wiersinga, A.P.J. Vlaar, and D. Sent. Journal of Intensive Care Medicine Letters 2021. Accompanying code and web application
• Efficient Monte Carlo methods for estimating failure probabilities with H.A. Darji, A. Imamura, M.K. Nakayama. Reliability Engineering and System Safety 2017.

Working Papers

• Learning Personalized Treatment Strategies with Predictive and Prognostic Covariates in Adaptive Clinical Trials with Stephen E. Chick and Spyros I. Zoumpoulis

Work in progress

• The Cost of Early Diagnosis of Thyroid Carcinoma with Calcitonin Tests with Reagan A. Collins, Tianna Herman, Jaber Valinejad, Mohammad S. Jalali, G. Scott Gazelle, Jagpreet Chhatwal, Carrie Lubitz
• Blood Transcriptomic Endotypes and the Response to Treatment Modalities in Sepsis: A Prospective Cohort Study with Niels van Mourik, Fabrice Uhel, Alexander Vlaar, Spyros I. Zoumpoulis, Stephen E. Chick, Brendon Scicluna

Conference Proceedings

• Expected Value of Information Methods for Contextual Ranking and Selection: Clinical Trials and Simulation Optimization with S.E. Chick and S. Zoumpoulis. Winter Simulation Conference 2021
• A Simulation Model to Evaluate the Patient Flow in an Intensive Care Unit Under Different Levels of Specialization with S.E. Chick, O. Lvova, and D. Sent. Winter Simulation Conference 2020.
• Extending a Bayesian Decision-Theoretic Approach to Value-Based Sequential Clinical Trial Design with S.E. Chick and M. Forster. Winter Simulation Conference 2018.
• Variance Reduction for Estimating a Failure Probability with Multiple Criteria with H.A. Darji, A. Imamura, M.K. Nakayama. Winter Simulation Conference 2016.